Trace Amines (TAs) & Trace Amine-Associated Receptors (TAARs)

TAs are endogenous chemical messengers and metabolites of amino acids1-3
  • Structurally similar to the monoamine neurotransmitters, dopamine, norepinephrine, and serotonin1-3
  • Expressed at levels at least 100-fold lower than corresponding neurotransmitters2
In 2001, TAs were found to selectively activate a family of receptors called TAARs1
  • Predominantly intracellular location2
  • Members of the G-protein coupled receptor family

Therapeutic Potential for TAAR1 Agonists: Preclinical Evidence1,3,4

  • Regulation of mood disorders including bipolar, depression, anxiety
  • Potential treatment of Parkinson’s disease psychosis
  • Management of sleep disorders
  • Utility in addiction (e.g. treatment of substance use disorders and compulsive binge eating)
​The safety and efficacy of TAAR1 agents have not been reviewed or approved by any drug/medicine regulatory agency and have no indication at this time. For use with medical professionals only.

TAAR1 is Expressed in a Number of Pathways Important to Schizophrenia5