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Adults
 | Approximately 3 percent of adults, 9.9 million people, live with bipolar disorder1 |
 | Onset of mood symptoms occur before age 20 in up to 60 percent of adults1-3 60 percent of adults with bipolar disorder are initially misdiagnosed with unipolar depression1
|
 | Many adult patients wait more than 10 years from the onset of symptoms to receive an accurate diagnosis of bipolar disorder1,4 |
Children and Adolescents
 | The lifetime prevalence of bipolar disorders is approximately 2 percent.6-8 Depressive symptoms are more common than manic symptoms in younger patients with bipolar disorder.9 |
Bipolar disorders will severely affect normal development and psychosocial functioning and increase the risk for behavioral, academic, and social problems, as well as substance abuse and suicide.10-12
Often under-diagnosed, many youth do not receive treatment for bipolar disorder or its comorbid conditions.13
References: 1. National Alliance on Mental Illness. Available at: https://www.nami.org/NAMI/media/NAMI-Media/Infographics/NAMI-You-Are-Not-Alone-FINAL.pdf. Accessed: Oct 2020. 2. Suppes T, et al. The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients. J Affect Disord. 2001;67(1-3):45. 3. Judd LL, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry. 2002;59(6):530. 4. Baldessarini RJ, et al. Effects of treatment latency on response to maintenance treatment in manic-depressive disorders. Bipolar Disord. 2007;9(4):386. 5. Hirschfeld RM, et al. Perceptions and impact of bipolar disorder: how far have we really come? Results of the National Depressive and Manic-Depressive Association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry. 2003;64(2):161. 6. Van Meter AR, et al. Meta-analysis of epidemiologic studies of pediatric bipolar disorder. J Clin Psychiatry. 2011;72:1250. 7. Kozloff N, et al. Bipolar disorder among adolescents and young adults: results from an epidemiological sample. J Affect Disord. 2010;125:350. 8. Goldstein BI, et al. The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord. 2017;19:524. 9. Cosgrove VE, et al. Bipolar depression in pediatric populations : epidemiology and management. Paediatr Drugs. 2013;15(2):83. 10. Birmaher B, et al. Bipolar Disorder. In: Lewis’ Child and Adolescent Psychiatry: A comprehensive textbook, 4th ed., Martin MA, Volkmar FR, Lewis M (Eds), Lippincott Williams & Wilkins, London 2007. 11. Pavuluri MN, et al. Pediatric bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 2005;44:846. 12. Grande I, et al. Bipolar disorder. Lancet. 2016;387:1561. 13. Khazanov GK, et al. Treatment patterns of youth with bipolar disorder: results from the National Comorbidity Survey-Adolescent Supplement (NCS-A). J Abnorm Child Psychol. 2015;43:391.
Adult Bipolar Disorder: Depressive Symptoms
 | 50% of adult patients with bipolar disorder experience depression as their first symptom1 On average adult patients with bipolar disorder experience 3 times more depression than mania2 |  |
 | In some cases, depressed mood without mood elevation can last for 5 years or more3 |
Adult Bipolar Disorder: Functional Impairment
 FAST, Functioning Assessment Short-Test. FAST score range, 0-72. Higher scores indicate greater disability, with a threshold score of 11 indicating the presence of significant disability. Rosa AR, et al. Value Health. 2010;13(8):984-988. |  IDS-C, Inventory of Depressive Symptomatology-Clinician Rated. IDS-C score range, 0-84. Higher scores indicate greater impairment. Altshuler LL, et al. J Clin Psychiatry. 2006;67(1):1551-1560. |
Adult Bipolar Disorder: Antidepressant Use
 | Antidepressant monotherapy is prescribed as first-line therapy for ~50% of adults diagnosed with bipolar disorder, twice as often as mood stabilizers4 Use of antidepressants in bipolar disorder may induce an affective switch to mania or hypomania5,6 Non-response to antidepressants may be an indicator of bipolar disorder and timely screening is recommended6 |  |
Adult Bipolar Disorder: Quality of Life
SF-36, Medical Outcomes Short Form 36-Item; US, United States.
SF-36 score range, 0-100. Lower scores indicate greater impairment.
Yatham LN, et al. Bipolar Disord. 2004;6(5):379-385.
References: 1. Suppes T, et al. The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients. J Affect Disord. 2001;67(1-3):45. 2. Judd LL, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry. 2002;59(6):530. 3. Perlis RH. Misdiagnosis of bipolar disorder. Am J Manag Care. 2005;11(9 suppl):S271. 4. Baldessarini RJ, et al. Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders. Psychiatr Serv. 2007;58(1):85-91. 5. Muzina DJ, et al. Differentiating bipolar disorder from depression in primary care. Cleve Clin J Med. 2007;74(2):89, 92, 95. 6. Manning JS. Tools to improve differential diagnosis of bipolar disorder in primary care. Prim Care Companion J Clin Psychiatry. 2010;12(suppl 1):17.
