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Approximately 3 percent of adults, 9.9 million people, live with bipolar disorder1
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Onset of mood symptoms occur before age 20 in up to 60 percent of adults1-3
60 percent of adults with bipolar disorder are initially misdiagnosed with unipolar depression1
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Many adult patients wait more than 10 years from the onset of symptoms to receive an accurate diagnosis of bipolar disorder1,4
Children and Adolescents
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The lifetime prevalence of bipolar disorders is approximately 2 percent.6-8
Depressive symptoms are more common than manic symptoms in younger patients with bipolar disorder.9
Bipolar disorders will severely affect normal development and psychosocial functioning and increase the risk for behavioral, academic, and social problems, as well as substance abuse and suicide.10-12
Often under-diagnosed, many youth do not receive treatment for bipolar disorder or its comorbid conditions.13
References: 1. National Alliance on Mental Illness. Available at: https://www.nami.org/NAMI/media/NAMI-Media/Infographics/NAMI-You-Are-Not-Alone-FINAL.pdf. Accessed: Oct 2020. 2. Suppes T, et al. The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients. J Affect Disord. 2001;67(1-3):45. 3. Judd LL, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry. 2002;59(6):530. 4. Baldessarini RJ, et al. Effects of treatment latency on response to maintenance treatment in manic-depressive disorders. Bipolar Disord. 2007;9(4):386. 5. Hirschfeld RM, et al. Perceptions and impact of bipolar disorder: how far have we really come? Results of the National Depressive and Manic-Depressive Association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry. 2003;64(2):161. 6. Van Meter AR, et al. Meta-analysis of epidemiologic studies of pediatric bipolar disorder. J Clin Psychiatry. 2011;72:1250. 7. Kozloff N, et al. Bipolar disorder among adolescents and young adults: results from an epidemiological sample. J Affect Disord. 2010;125:350. 8. Goldstein BI, et al. The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord. 2017;19:524. 9. Cosgrove VE, et al. Bipolar depression in pediatric populations : epidemiology and management. Paediatr Drugs. 2013;15(2):83. 10. Birmaher B, et al. Bipolar Disorder. In: Lewis’ Child and Adolescent Psychiatry: A comprehensive textbook, 4th ed., Martin MA, Volkmar FR, Lewis M (Eds), Lippincott Williams & Wilkins, London 2007. 11. Pavuluri MN, et al. Pediatric bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 2005;44:846. 12. Grande I, et al. Bipolar disorder. Lancet. 2016;387:1561. 13. Khazanov GK, et al. Treatment patterns of youth with bipolar disorder: results from the National Comorbidity Survey-Adolescent Supplement (NCS-A). J Abnorm Child Psychol. 2015;43:391.
Adult Bipolar Disorder: Depressive Symptoms
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50% of adult patients with bipolar disorder experience depression as their first symptom1
On average adult patients with bipolar disorder experience 3 times more depression than mania2
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In some cases, depressed mood without mood elevation can last for 5 years or more3
Adult Bipolar Disorder: Functional Impairment
FAST, Functioning Assessment Short-Test.
FAST score range, 0-72. Higher scores indicate greater disability, with a threshold score of 11 indicating the presence of significant disability.
Rosa AR, et al. Value Health. 2010;13(8):984-988.
IDS-C, Inventory of Depressive Symptomatology-Clinician Rated.
IDS-C score range, 0-84. Higher scores indicate greater impairment.
Altshuler LL, et al. J Clin Psychiatry. 2006;67(1):1551-1560.
Adult Bipolar Disorder: Antidepressant Use
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Antidepressant monotherapy is prescribed as first-line therapy for ~50% of adults diagnosed with bipolar disorder, twice as often as mood stabilizers4
Use of antidepressants in bipolar disorder may induce an affective switch to mania or hypomania5,6
Non-response to antidepressants may be an indicator of bipolar disorder and timely screening is recommended6
Adult Bipolar Disorder: Quality of Life
SF-36, Medical Outcomes Short Form 36-Item; US, United States.
SF-36 score range, 0-100. Lower scores indicate greater impairment.
Yatham LN, et al. Bipolar Disord. 2004;6(5):379-385.
References: 1. Suppes T, et al. The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients. J Affect Disord. 2001;67(1-3):45. 2. Judd LL, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry. 2002;59(6):530. 3. Perlis RH. Misdiagnosis of bipolar disorder. Am J Manag Care. 2005;11(9 suppl):S271. 4. Baldessarini RJ, et al. Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders. Psychiatr Serv. 2007;58(1):85-91. 5. Muzina DJ, et al. Differentiating bipolar disorder from depression in primary care. Cleve Clin J Med. 2007;74(2):89, 92, 95. 6. Manning JS. Tools to improve differential diagnosis of bipolar disorder in primary care. Prim Care Companion J Clin Psychiatry. 2010;12(suppl 1):17.